Survey Reveals Patients Lack Awareness of Differing Neuromodulator Ingredients
Posted By Madilyn Moeller, Thursday, October 2, 2025

From skincare to supplements, Americans are paying closer attention than ever to the ingredients in the products they use. Yet that attentiveness drops when it comes to injectable frown line treatments—despite being one of the most popular aesthetic procedures in the U.S., leaving many consumers unaware of key differences. New research commissioned by Talker Research on behalf of Revance uncovers a striking knowledge gap in ingredient awareness.
The national survey of 2,000 U.S. adults aged 30–54 revealed that:
- 91% of respondents are more ingredient-aware today than in the past.
- 61% of consumers say the top reason they research ingredients is to ensure a product works well, followed by managing allergies (41%) and understanding product differences (36%).
- 31% of respondents say AI tools have already helped them make smarter ingredient decisions.
While there is a notable increase in ingredient interest in other categories, a major blind spot remains for frown line treatments: fewer than half could recall any one ingredient in an available neurotoxin treatment on the market, and 53% mistakenly believe all formulations are “more or less the same”— despite significant differences. In fact, most respondents did not recognize that human or animal-based ingredients are common in many treatment formulations. By contrast, Daxxify is the only frown line treatment that has a peptide formulation and does not rely on human or animal-based components to stabilize the active ingredient.1
Among those polled, 36% said they chose their current frown line treatment because it was “the most obvious option,” while another 32% were unaware that alternatives even exist. Encouragingly, 61% said they’d switch to a different frown line treatment based on its ingredients/formula — signaling opportunity for education and awareness in aesthetics.
Revance is working to close that gap through a new educational campaign and landing page where consumers can learn more about what makes Daxxify different as the first and only neurotoxin frown line treatment with a peptide formulation.
Read more at Crown Aesthetics >>
