By MedResults

In today’s rapidly evolving aesthetic landscape, one reality is becoming impossible to ignore:

We are entering the era of regenerative medicine.

During a recent Age Reversal Academy masterclass, Dr. Chris Croley (Chief Medical Officer at Empire Medical Training and Chief Medical Advisor for MedResults) delivered an in-depth conversation about how combination therapies, exosomes, plasma technology, and topical biostimulants are transforming outcomes across aesthetic practices.

This article distills his live discussion into a structured format to present his clinical insights.

Why Combination Therapies Matter More Than Ever

Dr. Croley began by addressing something every aesthetic provider feels:

Patients want drastic, natural-looking results with minimal downtime — and they want them now.

Historically, providers relied on single-modality treatments. But as Dr. Croley explained:

“The most impressive results that I have in my practice, the ones that bring patients back again and again, are always from combination therapies. It’s never just one treatment.”

Why? Because biological aging and tissue damage involve multiple pathways — collagen breakdown, pigment dysregulation, cellular senescence, and extracellular matrix deterioration.

No single device or serum can address all of these at once. 

Combination therapy does.

The Shift Toward Regenerative, Not “Artificial,” Aesthetics

Dr. Croley noted a major market shift: patients no longer want the “overfilled” or “over-plumped” aesthetic of the past decade. They want their bodies to look naturally rejuvenated.

“We now have the science and technology to turn on signaling pathways we didn’t understand twenty years ago. We can stimulate true regenerative processes — safely — and with minimal downtime.”

This shift has propelled innovations such as:

• Exosomes
• PRP/PRF
• Clean plasma energy (Plexr)
• Topical biostimulants like Act O’ Firm, Act O’ Reverse, Act O’ Xome
• CD44 receptor activators
• A2A receptor modulation (PDRN)

Patients are demanding regenerative procedures, and providers must now speak this language fluently.

Understanding Cellular Aging and How Regenerative Therapies Intervene

Dr. Croley emphasized that all visible aging originates in one place:

The cell.

UV exposure, inflammation, oxidative stress, and lifestyle factors activate destructive genetic pathways that trigger:

• Pigment irregularities
• Elastin and collagen breakdown
• Rough texture
• Chronic inflammation
• Impaired wound healing

The goal of regenerative aesthetics is simple:

Stop, slow, or reverse these dysfunctional pathways.

The Problem With PRP Alone and Why Exosomes Changed Everything

PRP was one of Dr. Croley’s earliest tools in regenerative aesthetics. It remains valuable, but he learned something important:

“PRP depended too heavily on how healthy the patient was. Smokers, older patients, chronically ill patients… they didn’t respond the same.”

PRP works. Albeit inconsistently.

Exosomes, however, created a paradigm shift.

Why?

Because they are:

• Off-the-shelf
• Human-derived
• Highly standardized
• Potent cellular messengers
• Independent of patient health
• Rich in growth and signaling molecules

Exosomes deliver instructions, quite literally, to cells.

“Think of exosomes as messengers. They are little vesicles that tell surrounding cells exactly what to do: regenerate, repair, produce collagen, organize elastin, reduce pigment, restore balance.”

This is why the results are not just faster healing but longer-term structural improvement.

Business & Pricing Strategy: Why Regenerative Treatments Outperform Traditional Aesthetics

1. Stop Selling the Device — Sell the Result

Patients do not care what device you use. They care about:

• How fast they heal
• How natural the outcome looks
• How long do the results last
• Whether friends will notice the improvement

This is why regenerative combination therapies become premium treatments.

You’re not competing with Botox or a $250 microneedling session — you’re competing with surgical-like outcomes.

2. Regenerative Stacks Should Be Your Highest-ROI Procedures

For example:

“The moment results become visible, your patients become your marketers. Regenerative therapies have the highest repeat-purchase rate I’ve ever seen.”

3. Package Everything — Never Sell Single Sessions

Dr. Croley recommends:

• 3-treatment series (gold standard)
• Monthly memberships (for showers + exosomes)
• Annual skin regeneration plans (your highest retention product)

People don’t buy devices.

They buy transformation.

And transformation requires structure.

4. The Most Profitable Sentence in Aesthetics

“You’re not paying for the device.
You’re paying for the result and the biology behind it.”

This is where regenerative aesthetics wins:

Patients feel they’re getting something advanced, personalized, medical, and long-lasting.

What Makes MedResults Exosomes Different (from Dr. Croley’s experience)

Dr. Croley explained the science behind the Act O’ Xome formulation:

• Human-derived mesenchymal stem cell exosomes
• Ultrasonically separated for purity
• Mixed with 8 molecular weights of hyaluronic acid for deeper penetration
• Enhanced with:
  • 6 peptides (including copper tripeptide)
  • 13 amino acids
  • Niacinamide
  • Panthenol
  • Glutathione

This creates both immediate skin health benefits and long-term structural changes. And importantly:

“This is not true of every exosome on the market. Quality varies tremendously.”

The Act O’ Feel Line and CD44 Receptor Activation

Dr. Croley also broke down the Act O’ Feel product family:

• Act O’ Firm → Targets fibroblasts for collagen & elastin
• Act O’ Reverse → Adds pigment regulation for dyschromia
• Act O’ Xome → Combines exosomes + HA + peptides + amino acids

All three utilize activation of the CD44 receptor, a unique cellular pathway that signals fibroblasts to produce a new extracellular matrix without injection.

“After six to eight weeks, it can look like you injected filler — just from topical application with proper transdermal delivery.”

Why Plexr Clean Plasma is Superior for Transdermal Delivery

One of the strongest points Dr. Croley made:

“Microneedling clogs the channels you just created because of the pinpoint bleeding. Plexr shower does not. It creates perfect microchannels without bleeding.”

The benefits of Plexr shower:

• No numbing required
• No bleeding
• Minimal downtime
• Thousands of nano-ablation channels
• Superior product absorption
• Applicable across Fitzpatrick I–VI
• Safe compared to RF-plasma hybrids

The combination of Plexr + exosomes or Act O’ Feel products is what generates the “wow” results in his clinic.

Examples of Real Clinical Outcomes

Dr. Croley shared multiple impressive case results:

• Plexr Shower + Act O’ Reverse

Significant pigment reduction after two sessions.

• Acne and texture improvement

Remarkable changes in redness, lesions, and scarring.

• Vitiligo improvement

Early cases showing measurable repigmentation.

• Melasma in darker skin types

Unexpected resolution after only two sessions.

• Hair restoration

Using exosomes + Plexr cat scratch technique.

• Non-surgical blepharoplasty with greatly reduced downtime

These results reinforce his overall philosophy:

Regeneration > Aggression.

Exosomes vs. PDRN vs. PRP: When to Use What

Dr. Croley explained each tool works through a different pathway:

Exosomes → Cellular messaging 

PDRN → A2A receptor activation

Act O’ Feel (HA + CD44 activator) → Fibroblast signaling 

PRP → Platelet-derived growth factors

When combined, they target:

• Different receptors
• Different cellular pathways
• Different biological processes

This is what makes combination regenerative therapy so powerful.

Key Insight: Don’t Combine Similar Products. Combine Different Pathways.

Dr. Croley emphasized:

“I won’t combine three exosomes from different companies. But I will combine PRP + PDRN + exosomes + Act O’ Feel because they all work in different ways.”

This is the science of modern aesthetic synergy.

A Word of Caution About Exosome Injection

Dr. Croley made this very clear:

Exosome injections are not legal anywhere in the United States for aesthetics.
Only topical use is permitted.

Other countries have different rules, and injectable exosomes abroad often use different formulations.

Where to Begin If You Don’t Have Plexr Yet

One of the most important closing messages:

“Before I ever bought a Plexr, I used Act O’ Firm and Act O’ Reverse with microneedling — and my patients noticed the difference before I did.”

He reinforced that the topical line alone can dramatically enhance:

• Microneedling
• RF microneedling
• Ablative & non-ablative lasers
• CO₂
• Er:YAG
• Post-inflammatory recovery

Plexr elevates it even further — but the topicals are a legitimate starting point.

Conclusion: The Future Is Regenerative

Dr. Chris Croley’s webinar made one central truth clear:

We are no longer treating skin. We are treating cell behavior.

This is the new frontier of aesthetics —

not just resurfacing, not just filling, not just tightening —

but reprogramming the skin to function like younger skin again. And combination therapies are the key to unlocking it.

Register to access Dr. Croley’s Exosome masterclass and learn how to combine and use exosomes properly with different technologies.