PRP Activation Does Not Improve Growth Factor Secretion

Posted By American Med Spa Association, Thursday, March 3, 2022

An experimental research study led by Oliver J. Smith, PhD, titled "An Evaluation of the Effect of Activation Methods on the Release of Growth Factors from Platelet-Rich Plasma" (Journal of Plastic and Reconstructive Surgery, February 2022), investigated whether different methods of platelet-rich plamsa (PRP) activation affected growth factor release kinetics over time. 

The researchers ultimately discovered that the activation of PRP does not significantly improve growth factor secretion. 

Researchers processed PRP from 20 healthy volunteers (12 men and 8 women). The experiments were split into two stages with 10 volunteers each, and three PRP preparation methods for a total of six different preparation methods including: 

The analysis of the samples was conducted over 24 hours only to avoid the use of culture media. At one, four and 24 hours, a minimum of 0.13 ml of PRP supernatant was extracted and frozen at -80°C. Analysis of the supernatants was conducted within two weeks of the extraction.

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