In a split-face single-session comparison of platelet-rich plasma (PRP) and saline injections, recipients reported reduced signs of facial aging, according to a randomized clinical trial in JAMA Dermatology. 

The 27 participants, between the ages of 18 and 70, had bilateral cheek rhytids of Glogau class II or greater. Each patient received intradermal injections of PRP (3 mL total) in one cheek and sterile normal saline in the contralateral cheek.
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