In a groundbreaking study, a research team has found that chronic wounds in preclinical models were able to heal with normal, scar-free skin following treatment with an acellular product discovered at Mayo Clinic.
Derived from platelets, the purified exosomal product, known as ‘PEP’, was used to deliver healing messages into cells of preclinical animal models of ischemic wounds triggering wound healing and skin regeneration. The team documented the restoration of skin integrity, hair follicles, sweat glands, skin oils, and normal hydration. Ischemic wounds occur when arteries are clogged or blocked, preventing nutrients and oxygen from reaching the skin to trigger repair.
The research is supported by Mayo Clinic’s Center for Regenerative Medicine, and the study has been published in Theranostics.
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