BTX Ability to Contract Dermal Fibroblasts Varies by Formulation and Dilution

Posted By American Med Spa Association, Monday, October 7, 2019

Intradermal botulinum toxin injections can cause dermal fibroblast contraction, providing a lifting effect for facial rejuvenation, but this effect varies based on brand and dilution. In an effort to determine how—and whether—intradermal botulinum toxins create visible lifting in the midface, researchers Rungsima Wanitphakdeedecha MD, MA, MSc, et al, treated normal human dermal fibroblasts with onabotulinumtoxin (ONA), abobotulinumtoxin (ABO), prabotulinumtoxinA (PRABO), incobotulinumtoxinA (INCO), and letibotulinumtoxin A (LETI) in varying dilutions. They then photographed and measured the length of the fibroblasts every two hours from baseline to 12 hours post‐treatment.

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