IPL treatment in addition to fractional CO₂ laser offers better improvement in the appearance of hypertrophic scars than CO₂ alone. Researchers Alexander A. Daoud, MD, et al, performed a randomized controlled trial, that included 23 healthy adults with large (>100 cm²) hypertrophic scars who were randomized to one of three treatment arms: IPL and CO₂ ablative fractional laser (AFL), CO₂ AFL alone, and control (no laser treatment).

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