To assess the safety and efficacy of hyaluronic acid (HA)-based fillers to improve signs of aging, researchers conducted a prospective study of 20 patients. Lee et al found that multiple microinjections of HA-based gel filler were safe and effective for treating facial signs of aging.

Female patients aged 30 to 60 years (mean age 54.1 years) were included in the single-arm, open-label pilot study. Before the first injection at the initial visit, biophysical parameters of aging were measured and facial photographs were taken. Measured parameters included skin roughness, fine wrinkles, skin elasticity, facial lifting, skin pores, transepidermal water loss (TEWL), skin glossiness, and skin hydration.

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